Advantage Multi®

Compare Advantage Multi® for Dogs (imidacloprid + moxidectin) with other parasite preventives

Compare Advantage Multi® for Dogs (imidacloprid + moxidectin) with other parasite preventives

All dogs need heartworm prevention, but what kind of protection should you give them from other parasites, such as fleas and intestinal worms? Use our comparison charts to explore the differences between Advantage Multi® for Dogs and other preventives.* All products require a veterinarian’s prescription.

Advantage Multi® for Dogs vs. REVOLUTION® >
Advantage Multi® vs. Heartgard PLUS® >
Advantage Multi® for Dogs vs. Sentinel® >
Advantage Multi® for Dogs vs. ProHeart® 6 and 12 >
Advantage Multi® for Dogs vs. Simparica TRIO® >

*Based on label indications: parasites and life stages.
Advantage Multi for dogs product box with competitor logos

Advantage Multi® for Dogs vs. REVOLUTION®

logos of Advantage Multi vs Revolution
Topical heartworm and flea preventives that treat other parasites differently

Both Advantage Multi® for Dogs and REVOLUTION® are monthly topical treatments that prevent heartworms, kill fleas and treat sarcoptic mange, a skin infection caused by parasitic mites. Your choice may depend on whether your dog is more prone to intestinal worms, ear mites or ticks. 

Swipe to explore more differences. 
 

heartworm treatment comparison chart of Advantage Multi vs Revolution
Advantage Multi® provides thorough heartworm protection

Both products prevent heartworms, but only Advantage Multi® also kills heartworm offspring (microfilariae), up to 60,000 of which can live in a few drops of blood. Killing offspring helps prevent the spread of heartworm to other dogs: When a mosquito bites a heartworm-positive dog and then bites another dog, it can pass on heartworm larvae.  

intestinal worms comparison chart of Advantage Multi vs Revolution
Advantage Multi® kills multiple intestinal worms

If your dog frequently plays outside, visits dog parks, eats soil or feces, or chases wildlife, they could be at greater risk for contracting intestinal worms. Advantage Multi® kills three common and dangerous intestinal parasites — roundworms, hookworms and whipworms — while REVOLUTION® for dogs kills none. 

ear mites treatment comparison chart of Advantage Multi vs Revolution
REVOLUTION® treats ear mites

Homeless, shelter and stray dogs are more prone to ear mites than family dogs. REVOLUTION® treats ear mites while Advantage Multi® does not. 

american ticks treatment comparison chart of Advantage Multi vs Revolution
REVOLUTION® kills American dog ticks

Do you hike with your dog in heavily wooded areas? Your pup may be more at risk for multiple species of ticks. REVOLUTION® kills one species — American dog ticks — while Advantage Multi® does not. Talk to your vet if you’re looking for a broad-spectrum tick control product for your dog. 

Advantage Multi® for Dogs vs. REVOLUTION® comparison chart

  Advantage Multi® logo with ingredients (imidacloprid + moxidectin) Revolution® logo
FORM/DOSE Topical, monthly Topical, monthly
PREVENTS HEARTWORMS YES YES
KILLS HEARTWORM OFFSPRING (MICROFILARIAE) YES NO
KILLS FLEAS  YES YES
KILLS ROUNDWORMS YES NO
KILLS HOOKWORMS YES NO
KILLS WHIPWORMS YES NO
TREATS SARCOPTIC MANGE YES YES
TREATS EAR MITES NO YES
KILLS AMERICAN DOG TICKS NO YES

 

Advantage Multi® for Dogs vs. HEARTGARD Plus®

logos of Advantage Multi vs Heartgard Plus
Worm treatments with different levels of protection from other parasites

Advantage Multi® for Dogs, a topical treatment, and HEARTGARD Plus®, a chewable tablet, both prevent heartworms and kill two types of intestinal worms: Roundworms and hookworms. But Advantage Multi® for Dogs treats more internal and external parasites. 

Swipe to explore more differences. 
 

heartworm treatment comparison chart of Advantage Multi vs Heartgard Plus
Advantage Multi® provides thorough heartworm protection

Both products prevent heartworms, but only Advantage Multi® also kills heartworm offspring (microfilariae), up to 60,000 of which can live in a few drops of blood. Killing offspring helps prevent the spread of heartworm to other dogs: When a mosquito bites a heartworm-positive dog and then bites another dog, it can pass on heartworm larvae.  

flea treatment comparison chart of Advantage Multi vs Heartgard Plus
Advantage Multi® kills fleas through contact

Fleas are a common parasite affecting dogs. Advantage Multi® kills fleas through contact so they don’t have to bite your dog to die. HEARTGARD Plus®, primarily a worm protection product, does not provide flea prevention.

intestinal worms treatment comparison chart of Advantage Multi vs Heartgard Plus
Advantage Multi® kills more intestinal parasites

If your dog frequently plays outside, visits dog parks, eats soil or feces, or chases wildlife, they may be more prone to multiple types of intestinal worms. Advantage Multi® kills more common and harmful intestinal worms — roundworms and whipworms — as well as hookworms. HEARTGARD Plus® only kills roundworms and hookworms. 

sarcoptic mange treatment comparison chart of Advantage Multi vs Heartgard Plus
Advantage Multi® treats and controls sarcoptic mange

Does your dog come into close contact with other pups in doggie daycares, dog parks or groomers? They may be more likely to get sarcoptic mange, a skin infection caused by parasitic mites. Advantage Multi® treats and controls this highly contagious condition while HEARTGARD Plus® does not. 

Advantage Multi® for Dogs vs. HEARTGARD Plus® comparison chart

  Advantage Multi® logo with ingredients (imidacloprid + moxidectin) Heartgard® Plus logo
FORM/DOSE Topical, monthly Oral, monthly
PREVENTS HEARTWORMS YES YES
KILLS HEARTWORM OFFSPRING (MICROFILARIAE) YES NO
KILLS FLEAS YES NO
TREATS SARCOPTIC MANGE YES NO
KILLS ROUNDWORMS YES YES
KILLS HOOKWORMS YES YES
KILLS WHIPWORMS YES NO

 

Advantage Multi® for Dogs vs. SENTINEL® FLAVOR TABS®§

logos of Advantage Multi vs Sentinel
Similar heartworm preventives that treat fleas differently

Advantage Multi® for Dogs, a topical treatment, and SENTINEL® FLAVOR TABS®, a chewable tablet, both protect against heartworms and intestinal worms. But they treat fleas and other parasites in different ways. 

Swipe to explore more differences. 
 

heartworm treatment comparison chart of Advantage Multi vs Sentinel
Advantage Multi® provides thorough heartworm protection

Both products prevent heartworms, but only Advantage Multi® also kills heartworm offspring (microfilariae), up to 60,000 of which can live in a few drops of blood. Killing offspring helps prevent the spread of heartworm to other dogs: When a mosquito bites a heartworm-positive dog and then bites another dog, it can pass on heartworm larvae.  

flea treatment comparison chart of Advantage Multi vs Sentinel
Flea treatment differences

Fleas are a common parasite affecting dogs. Advantage Multi® for Dogs kills fleas through contact, which means they don’t have to bite your dog to die. SENTINEL® FLAVOR TABS® kills flea eggs and larvae but is not effective against existing fleas on your dog. That means fleas could continue to bite and feed on your dog until they die on their own or are groomed off by your dog.

sarcoptic mange treatment comparison chart of Advantage Multi vs Sentinel
Advantage Multi® treats and controls sarcoptic mange

Does your dog come into close contact with other pups at dog parks, doggie daycares or groomers? They may be more likely to get sarcoptic mange, a skin infection caused by parasitic mites. Advantage Multi® treats and controls this highly contagious condition while SENTINEL® FLAVOR TABS® does not. 

intestinal worms treatment comparison chart of Advantage Multi vs Sentinel
Different intestinal worm treatments

If your dog frequently plays outside, visits dog parks, eats soil or feces, or chases wildlife, they may be more prone to multiple types of intestinal worms. Advantage Multi® provides thorough protection against intestinal worms by killing both immature and adult roundworms and hookworms as well as whipworms. SENTINEL® FLAVOR TABS® only kills adult roundworms and hookworms and whipworms. 

Advantage Multi® for Dogs vs. SENTINEL® FLAVOR TABS® comparison chart

  Advantage Multi® logo with ingredients (imidacloprid + moxidectin) Sentinel® Spectrum logo
FORM/DOSE Topical, monthly Oral, monthly
PREVENTS HEARTWORMS YES YES
KILLS HEARTWORM OFFSPRING (MICROFILARIAE) YES NO
KILLS ADULT FLEAS YES NO
KILLS FLEAS THROUGH CONTACT, NO BITING REQUIRED YES NO
PREVENTS FLEA INFESTATIONS YES YES
TREATS SARCOPTIC MANGE YES NO
KILLS IMMATURE ROUNDWORMS YES NO
KILLS ADULT ROUNDWORMS YES YES
KILLS IMMATURE HOOKWORMS YES NO
KILLS ADULT HOOKWORMS YES YES
KILLS WHIPWORMS YES YES

 

Advantage Multi® for Dogs vs. ProHeart® 6 and ProHeart® 12**

logos of Advantage Multi vs ProHeart 6 and ProHeart 12
Heartworm preventives with different dosing schedules

Both Advantage Multi® for Dogs and ProHeart® prevent heartworms, but in different ways: Advantage Multi® is a monthly topical application, while ProHeart® is an injection given once or twice a year at your veterinarian’s office. Although ProHeart® offers less frequent treatments, it treats no external parasites. 

Swipe to explore more differences. 
 

heartworm treatment comparison chart of Advantage Multi vs ProHeart
Advantage Multi® provides thorough heartworm protection

Both products prevent heartworms, but only Advantage Multi® also kills heartworm offspring (microfilariae), up to 60,000 of which can live in a few drops of blood. Killing offspring helps prevent the spread of heartworm to other dogs: When a mosquito bites a heartworm-positive dog and then bites another dog, it can pass on heartworm larvae.  

flea treatment comparison chart of Advantage Multi vs ProHeart
Advantage Multi® kills fleas

Fleas are a common parasite affecting dogs. Advantage Multi® for Dogs kills fleas through contact, which means they don’t have to bite your dog to die. ProHeart® does not treat fleas.

intestinal worms treatment comparison chart of Advantage Multi vs ProHeart
Advantage Multi® kills more intestinal worms

If your dog frequently plays outside, visits dog parks, eats soil or feces, or chases wildlife, they may be more prone to multiple types of intestinal worms. Advantage Multi® provides thorough, broad spectrum protection against intestinal worms by killing roundworms and hookworms and whipworms. ProHeart® only kills hookworms. 

sarcoptic mange treatment comparison chart of Advantage Multi vs ProHeart
Advantage Multi® treats and controls sarcoptic mange

Does your dog come into close contact with other pups at groomers, dog parks or doggie daycares? They may be more at risk for sarcoptic mange, a skin infection caused by parasitic mites. Advantage Multi® treats and controls this highly contagious condition while ProHeart® does not. 

Advantage Multi® for Dogs vs. ProHeart® comparison chart

  Advantage Multi® logo with ingredients (imidacloprid + moxidectin) ProHeart® 12 logo
FORM/DOSE Topical, monthly Injection, every 6 or 12 months
PREVENTS HEARTWORMS YES YES
KILLS HEARTWORM OFFSPRING (MICROFILARIAE) YES NO
KILLS FLEAS YES NO
TREATS SARCOPTIC MANGE YES NO
KILLS IMMATURE ROUNDWORMS YES NO
KILLS ADULT ROUNDWORMS YES NO
KILLS IMMATURE HOOKWORMS YES YES
KILLS ADULT HOOKWORMS YES YES
KILLS WHIPWORMS YES NO

 

Advantage Multi® for Dogs vs. Simparica TRIO™††

logos of Advantage Multi vs Simparica Trio
Heartworm and flea preventives that treat other parasites differently

Both Advantage Multi® for Dogs, a topical treatment, and Simparica TRIO™, a chewable tablet, prevent heartworms and kill fleas. Your choice may depend on your dog’s lifestyle and whether intestinal worms, ticks or sarcoptic mange pose a greater risk. 

Swipe to explore more differences. 
 

heartworm treatment comparison chart of Advantage Multi vs Simparica Trio
Advantage Multi® provides thorough heartworm protection

Both products prevent heartworms, but only Advantage Multi® also kills heartworm offspring (microfilariae), up to 60,000 of which can live in a few drops of blood. Killing offspring helps prevent the spread of heartworm to other dogs: When a mosquito bites a heartworm-positive dog and then bites another dog, it can pass on heartworm larvae.  

flea treatment comparison chart of Advantage Multi vs Simparica Trio
Flea treatment differences

Fleas are a common parasite affecting dogs. Advantage Multi® for Dogs kills fleas through contact, which means they don’t have to bite your dog to die. Simparica TRIO™ requires fleas to bite your dog and ingest blood to die. 

intestinal worms treatment comparison chart of Advantage Multi vs Simparica Trio
Advantage Multi® kills more intestinal parasites

If your dog frequently plays outside, visits dog parks, eats soil or feces, or chases wildlife, they may be more prone to multiple types of intestinal worms. Advantage Multi® provides thorough, broad spectrum protection against intestinal worms by killing roundworms and hookworms and whipworms. Simparica TRIO™ only kills hookworms and roundworms.  

sarcoptic mange treatment comparison chart of Advantage Multi vs Simparica Trio
Advantage Multi® treats and controls sarcoptic mange

Does your dog come into close contact with other pups at doggie daycares, groomers or dog parks? They may be more prone to sarcoptic mange, a skin infection caused by parasitic mites. Advantage Multi® treats and controls this highly contagious condition while Simparica TRIO™ does not. 

american tick treatment comparison chart of Advantage Multi vs Simparica Trio
Simparica TRIO™ kills ticks

Have you ever seen a tick on your dog? Your pup may be more prone to ticks. Simparica TRIO™ kills ticks while Advantage Multi® does not. 

Advantage Multi® for Dogs vs. Simparica TRIO™ comparison chart

  Advantage Multi® logo with ingredients (imidacloprid + moxidectin) Simparica Trio logo
FORM/DOSE Topical, monthly Oral, monthly
PREVENTS HEARTWORMS YES YES
KILLS HEARTWORM OFFSPRING (MICROFILARIAE) YES NO
KILLS ADULT FLEAS YES YES
KILLS FLEAS THROUGH CONTACT, NO BITING REQUIRED YES NO
PREVENTS FLEA INFESTATIONS YES YES
TREATS SARCOPTIC MANGE YES NO
KILLS IMMATURE ROUNDWORMS YES YES
KILLS ADULT ROUNDWORMS YES YES
KILLS IMMATURE HOOKWORMS YES NO
KILLS ADULT HOOKWORMS YES YES
KILLS WHIPWORMS YES NO
KILLS TICKS NO YES

 

Ready to provide your dog with the multiple benefits of Advantage Multi®?